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KMID : 0613820090190121777
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Journal of Life Science
2009 Volume.19 No. 12 p.1777 ~ p.1786
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Analysis of Thymosin β4 and Vascular Endothelial Cell Growth Factor (VEGF) Expression in Normal Human Tissues Using Tissue Microarray
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Ock Mee-Sun
Cha Hee-Jae
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Abstract
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Thymosin β4, a small protein containing 43 amino acids, has multi-functional roles in cell physiology. It was first identified as a thymic maturation factor and recently has been shown to accelerate wound healing, hair growth, angiogenesis, tumor growth, and metastasis. It was also reported to play a key role in developing organs, including the nervous system and heart. Thymosin β4 induces the expression of vascular endothelial cell growth factor (VEGF), laminin-5, and other important biologically active genes. Using tissue microarray analysis, we investigated the expression patterns of thymosin β4 and VEGF in various normal human adult tissues. Thymosin β4 was highly expressed in the liver, pancreas, ductal epithelium of the salivary gland, and heart, and moderately expressed in the skin, lung, spleen, lymph node, thymus, ureter, and blood endothelial cells in both the lung and adrenal gland. The expression of VEGF generally co-localized with thymosin β4 and VEGF was highly expressed in the pancreas, ureter, mammary gland, liver, esophagus, and blood endothelial cells in both the lung and adrenal gland. These results suggest that thymosin β4 plays an important role in the function of various organs and since the expression pattern of thymosin β4 co-localized with VEGF, part of that function may be to induce or maintain angiogenesis.
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KEYWORD
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Thymosin β4, VEGF, human normal tissue, immunohistochemistry, tissue microarray
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